ECMIS 2019
2-5 June: Het Pand – Ghent University

Sunday 2 June
17:00-18:00 Registration
18:00 Opening Introduction
Keynote lectures
Chairman: Bruno Goddeeris
18:05-18:50 „ Role of the maternal microbiota in shaping gene expression and microbiota composition in the offspring intestine” by Stephanie Ganal-Vonarburg, Department for BioMedical Research, University of Bern, Switzerland
18:50-19:30 „ Cathelicidins, host defense peptides against E. coli infectionby Henk Haagsman, University of Utrecht, The Netherlands
19:30 Reception

Monday 3 June
Chairmen: Meryem Aloulou and Eric Cox
Mucosal immune responses
9:00 Keynote lecture:T-dependent humoral responses in mucosal sitesby Aloulou Meryem, CRCN, INSERM, Center for Pathophysiology of Toulouse Purpan, Toulouse University, France
Modulation of the host
9:40 Keynote lecture:New insights regarding the interplay between Shigella and human lymphocytesby Katja Brunner, Institut Pasteur, France
10:20-10.50 Coffee break
10:50 Selected oral presentations
10:50 The effects of β-1,3-1,6 glucans on innate immune responses in pigs by Leen Hermans, Ghent University, Belgium.
11:10 The pathogenic mechanisms of QS-1 in Avian Pathogenic
E. coli by Guoqiang Zhu, Yangzhou University, China.
11:30 – 13:00 Lunch and poster session

Chairmen James M. Fleckenstein and Bert Devriendt
13:00 Keynote lecture: „Remodeling of intestinal epithelial architecture by enterotoxigenic E. coli by James M. Fleckenstein, Washington University School of Medicine, Missouri, USA.
Selected oral presentations
13:40 Porcine small intestinal enteroids as a model to explore host-pathogen interactions by Bjarn Vermeire, Ghent University, Belgium.
Escherichia coli ST131: a versatile multidrug-resistant pathogen in and outside the gut by Makrina Totsika, Queensland University of Technology, Australia
14:20 – 14:50
Coffee break
Modulation of E. coli by the host
Chairmen: Åsa Sjöling and Jacques Mainil
14:50 Keynote lecture Bile salts and other host factors regulate expression of ETEC virulence genes by Åsa Sjöling, Department of Microbiology, Tumor and Cell Biology (MTC), Karolinska Institute, Sweden
Selected oral presentations
15:30 Oxygen and contact with human intestinal epithelium independently stimulate virulence gene expression in enteroaggregative Escherichia coli, by Stephanie Schüller, University of University of East Anglia, UK.
15:50 Quorum sensing signal Acyl-Homoserine Lactones enhance the acid resistance of Enteropathogenic
Escherichia coli O157:H7 by activating the rpoS and gad system, Guoqiang Zhu, Yangzhou University, China
Finish of day one
17:30 Guided tour in the Historical Centre of Ghent or Bruges (by bus)

Tuesday 4 June
Chairmen: Edward G. Dudley and Marc Heyndrickx
Modulation of E. coli by the environment
9:00 Keynote lecture: “Stx Phages and their inductionby Frederic Auvray, Digestive Health Research Institute (IRSD: UMR INSERM 1220, INRA 1416, ENVT, UT3), France
9:40 Keynote lecture: “Commensal E. coli that enhance toxin production by E. coli O157:H7” by Edward G. Dudley, The Pennsylvania State University, US
10:20-10:50 Coffee break
10:50 Selected oral presentations
10:50. Inactivation of stx-phages by probiotic E. coli strain Nissle 1917, by Soundararajan M, Institute for Molecular Infection Biology, Wuerzburg, Germany.
11.10. Vitamin K influences the virulence potential of Enterohemorrhagic
Escherichia coli, Kijewski Anne, Norwegian Institute of Life Sciences, Norway.
11:30 – 13.30 Lunch
12.00 – 13.30 Poster sessions – Walking tour

Chairmen: Christina Schäffer and Henri De Greve
Host-pathogen interaction at the receptor level
13:30 Keynote lecture: „Possible roles of glycobiology for establishment and persistence of bacteria in the host ” by Christina Schäffer, BOKU University of Natural Resources and Life Sciences, Austria
Preventive measures
14:10 Keynote lecture: “Receptor analogues as strategy to prevent E. coli infection ” by Eric Cox, Ghent University, Belgium
Coffee break
15:10 Selected oral presentations
15.10 Human cellular and humoral immune responses against colonization factors and mucinase YghJ after experimental infection with an epidemiologically relevant STh-only ETEC strain, Hanevik K., University of Bergen, Norway
15.30. Improved weight gain and reduced mortality following oral vaccination of pigs with Coliprotect® F4, Vangroenewhege Frédéric, Elanco Animal Health, Belgium
15.50. Antibodies derived from STatoxoid-mnLTR192G/L211A toxoid fusions induce neutralizing antibody against LT and STa but show little cross-reactivity with guanylin or uroguanylin. Duan QQ, Yangzhou University, China
Keynote lecture: “In feed administered non-encapsulated monomeric porcine IgA antibodies produced in yeast as prophylaxis against F4-mediated colibacillosis in pigs” by Vikram Virdi, UGent/VIB, Ghent, Belgium
Finish Day 2
Symposium Dinner in the the beautiful Thagaste Monastery in the historic heart of Ghent

Wednesday 5 June
Chairmen: Ann-Mari Svennerholm and Weiping Zhang
New vaccination strategies
9:00 Keynote Lecture: ”New oral vaccination strategies based on the interaction of enterotoxigenic E. coli with the intestinal mucosa” by Bert Devriendt Ghent University, Belgium
9:40 Selected oral presentations
9.40 A Phase 1 Dose Escalating Study of a Prototype CS6 Subunit Vaccine with a Modified Heat-labile Enterotoxin from Enterotoxigenic Escherichia coli (ETEC). Lee T.K., Naval, Medical Research Center, US.
10.00 Intramuscular vaccination with CssBA, a CS6-subunit vaccine candidate against enterotoxigenic E. coli (ETEC), and LT(R192G/L211A) as adjuvant promotes antigen-specific α4β7+ antibody-secreting cells. Milton Maciel, Henry M. Jackson Foundation and Naval Medical Research Center, US.

Coffee break
10:50 Keynote lecture”New strategies in development of vaccines against ETEC” by Weiping Zhang University of Illinois, US
Selected oral presentation
11.30 Development of a multivalent, multipathogen conjugate vaccine platform for protection against three major enteric pathogens Enterotoxigenic Escherichia coli, Shigella and Campylobacter jejuni, Laird RM, Henry M. Jackson Foundation for the Advancement of Military Medicine and Naval Medical Research Center, US.

Chairman: Eric Cox
11:50 Keynote lecture:
Clinical trials of an oral ETEC vaccine, ETVAX, in children in developing countries and in travelers by Ann-Mari Svennerholm, Department of Microbiology and Immunology, University of Gothenburg, Sweden
12:30 Closure and Farewell Lunch